Platelet glycoprotein GPIIb-IIIa complex: Difference between revisions
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'''Platelet Glycoprotein GPIIb-IIIa Complex''' is a "platelet membrane glycoprotein complex important for platelet adhesion and aggregation. it is an integrin complex containing integrin alphaiib and integrin beta3 which recognizes the arginine-glycine-aspartic acid (rgd) sequence present on several adhesive proteins. as such, it is a receptor for fibrinogen; von Willebrand factor; fibronectin; vitronectin; and thrombospondins."<ref name="MeSH-2b-3a">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?term=Platelet+Glycoprotein+GPIIb-IIIa+Complex |title=Platelet Glycoprotein GPIIb-IIIa Complex |accessdate=2008-01-10 |author=Anonymous |authorlink= |coauthors= |date= |format= |work= |publisher=National Library of Medicine |pages= |language= |archiveurl= |archivedate= |quote=}}</ref> | |||
==Role in medicine== | ==Role in medicine== | ||
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Antibodies to GPIIb-IIIa is the cause of most cases of chronic [[idiopathic thrombocytopenic purpura]] (ITP). | Antibodies to GPIIb-IIIa is the cause of most cases of chronic [[idiopathic thrombocytopenic purpura]] (ITP). | ||
Antibodies to immune complexes of GPIIb-IIIa and various drugs | Antibodies to immune complexes of GPIIb-IIIa and various drugs underlie many cases of drug-induced immune [[thrombocytopenia]].<ref name="pmid17687133">{{cite journal |author=Aster RH, Bougie DW |title=Drug-induced immune thrombocytopenia |journal=N. Engl. J. Med. |volume=357 |issue=6 |pages=580–7 |year=2007 |pmid=17687133 |doi=10.1056/NEJMra066469|url=http://content.nejm.org/cgi/content/full/357/6/580}}</ref> | ||
[[Glycoprotein IIb/IIIa inhibitors]] | [[Glycoprotein IIb/IIIa inhibitors]] (GPIs), such as [[eptifibatide]] and [[tirofiban]], block the platelet glycoprotein GPIIb-IIIa complex and inhibit platelet aggregation. They arp used to treat [[vascular disease]]s. | ||
==References== | ==References== | ||
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** [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&TermToSearch=3674 Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)] | ** [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&TermToSearch=3674 Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)] | ||
* [http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?l273800 OMIM Gene map] | * [http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?l273800 OMIM Gene map] | ||
Latest revision as of 21:55, 14 February 2010
Platelet Glycoprotein GPIIb-IIIa Complex is a "platelet membrane glycoprotein complex important for platelet adhesion and aggregation. it is an integrin complex containing integrin alphaiib and integrin beta3 which recognizes the arginine-glycine-aspartic acid (rgd) sequence present on several adhesive proteins. as such, it is a receptor for fibrinogen; von Willebrand factor; fibronectin; vitronectin; and thrombospondins."[1]
Role in medicine
A deficiency of GPIIb-IIIa is the cause of Glanzman Thrombasthenia, which causes a prolonged bleeding time.
Antibodies to GPIIb-IIIa is the cause of most cases of chronic idiopathic thrombocytopenic purpura (ITP).
Antibodies to immune complexes of GPIIb-IIIa and various drugs underlie many cases of drug-induced immune thrombocytopenia.[2]
Glycoprotein IIb/IIIa inhibitors (GPIs), such as eptifibatide and tirofiban, block the platelet glycoprotein GPIIb-IIIa complex and inhibit platelet aggregation. They arp used to treat vascular diseases.
References
- ↑ Anonymous. Platelet Glycoprotein GPIIb-IIIa Complex. National Library of Medicine. Retrieved on 2008-01-10.
- ↑ Aster RH, Bougie DW (2007). "Drug-induced immune thrombocytopenia". N. Engl. J. Med. 357 (6): 580–7. DOI:10.1056/NEJMra066469. PMID 17687133. Research Blogging.