Platelet glycoprotein GPIIb-IIIa complex: Difference between revisions
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==References== | ==References== | ||
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==External links== | |||
* [http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?term=Platelet+Glycoprotein+GPIIb-IIIa+Complex MeSH] | |||
* Entrez Gene | |||
** [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&TermToSearch=3690 Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)] | |||
** [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&TermToSearch=3674 Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)] | |||
* [http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?l273800 OMIM Gene map] | |||
[[Category:CZ Live]] [[Category:Health Sciences Workgroup]] | [[Category:CZ Live]] [[Category:Health Sciences Workgroup]] | ||
Revision as of 09:13, 11 January 2008
Platelet Glycoprotein GPIIb-IIIa Complex is a "platelet membrane glycoprotein complex important for platelet adhesion and aggregation. it is an integrin complex containing integrin alphaiib and integrin beta3 which recognizes the arginine-glycine-aspartic acid (rgd) sequence present on several adhesive proteins. as such, it is a receptor for fibrinogen; von Willebrand factor; fibronectin; vitronectin; and thrombospondins."[1]
Role in medicine
A deficiency of GPIIb-IIIa is the cause of Glanzman Thrombasthenia, which causes a prolonged bleeding time.
Antibodies to GPIIb-IIIa is the cause of most cases of chronic idiopathic thrombocytopenic purpura (ITP).
Glycoprotein IIb/IIIa inhibitors are platelet aggregation inhibitors used to treat cardiovascular diseases.
References
- ↑ Anonymous. Platelet Glycoprotein GPIIb-IIIa Complex. National Library of Medicine. Retrieved on 2008-01-10.