Beta-2 adrenergic receptor: Difference between revisions
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After binding, [[signal transduction]] activates the [[second messenger system]]s adenyl cyclase-[[cyclic AMP]] primarily and also [[cyclic GMP]] which then activates [[protein kinase]]s. | After binding, [[signal transduction]] activates the [[second messenger system]]s adenyl cyclase-[[cyclic AMP]] primarily and also [[cyclic GMP]] which then activates [[protein kinase]]s. | ||
[[Adrenergic beta-agonist]]s, such as [[terbutaline]], are used to treat [[asthma]] by preventing bronchoconstriction. | [[Adrenergic beta-agonist]]s, such as [[terbutaline]], are used to treat [[asthma]] by preventing bronchoconstriction. [[Adrenergic beta-antagonist]]s, such as [[atenolol]] or [[metoprolol]] are used to treat cardiac diseases. | ||
==External links== | ==External links== | ||
Revision as of 21:18, 12 January 2011
In medicine and physiology, beta-2 adrenergic receptors, or β-2 adrenergic receptors, are cell surface receptors of the G-protein-coupled receptor type that are in the sympathetic nervous system. Beta-2 adrenergic receptors are a "subclass of beta-adrenergic receptors (receptors, adrenergic, beta). Beta-2 Adrenergic receptors are more sensitive to epinephrine than to norepinephrine and have a high affinity for the agonist terbutaline. They are widespread, with clinically important roles in skeletal muscle, liver, and vascular, bronchial, gastrointestinal, and genitourinary smooth muscle."[1] Their functions include vasodilation.
After binding, signal transduction activates the second messenger systems adenyl cyclase-cyclic AMP primarily and also cyclic GMP which then activates protein kinases.
Adrenergic beta-agonists, such as terbutaline, are used to treat asthma by preventing bronchoconstriction. Adrenergic beta-antagonists, such as atenolol or metoprolol are used to treat cardiac diseases.
External links
References
- ↑ Anonymous (2024), Beta-2 adrenergic receptor (English). Medical Subject Headings. U.S. National Library of Medicine.