Kallikrein-kinin system: Difference between revisions
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The '''kinin | The '''kallikrein-kinin system''' is a "system of metabolic interactions by products produced in the distal nephron of the [[kidney]]. These products include kallikrein; [[kinins]]; kininase I; kininase II; and enkephalinase. This system participates in the control of renal functions. It interacts with the [[Renin-angiotensin system | renin-angiotensin-aldosterone system]] to regulate [[blood pressure]], generation of [[prostaglandin]]s, release of [[vasopressin]]s, and water-electrolyte balance"<ref>{{MeSH}}</ref> | ||
==Components and mechanisms== | |||
Kallikreins are serine endopeptidase (proteases) that act on kininogens to form the kinins [[bradykinin]] and kalidin.<ref name="isbn0-07-144040-2p578">{{cite book |author=Ganong, William F. |title=Review of medical physiology |publisher=McGraw-Hill Medical |location= |year=2005 |pages=578 |isbn=0-07-144040-2 |oclc= |doi=}}</ref> There are three types of kallikreins: | |||
* Tissue kallikrein | |||
* Plasma kallikrein activates Factor XII to initiate the instrinsic pathway of [[coagulation]]. | |||
* [[Prostate-specific antigen]] | |||
Kininase I and kininase II inactivate [[bradykinin]] and kalidin.<ref name="isbn0-07-144040-2p577">{{cite book |author=Ganong, William F. |title=Review of medical physiology |publisher=McGraw-Hill Medical |location= |year=2005 |pages=577 |isbn=0-07-144040-2 |oclc= |doi=}}</ref> Kininase II, formally called [[peptidyl-dipeptidase A]], is the same enzyme as angiotensin converting enzyme. | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 00:25, 16 June 2008
The kallikrein-kinin system is a "system of metabolic interactions by products produced in the distal nephron of the kidney. These products include kallikrein; kinins; kininase I; kininase II; and enkephalinase. This system participates in the control of renal functions. It interacts with the renin-angiotensin-aldosterone system to regulate blood pressure, generation of prostaglandins, release of vasopressins, and water-electrolyte balance"[1]
Components and mechanisms
Kallikreins are serine endopeptidase (proteases) that act on kininogens to form the kinins bradykinin and kalidin.[2] There are three types of kallikreins:
- Tissue kallikrein
- Plasma kallikrein activates Factor XII to initiate the instrinsic pathway of coagulation.
- Prostate-specific antigen
Kininase I and kininase II inactivate bradykinin and kalidin.[3] Kininase II, formally called peptidyl-dipeptidase A, is the same enzyme as angiotensin converting enzyme.
References
- ↑ Anonymous (2024), Kallikrein-kinin system (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Ganong, William F. (2005). Review of medical physiology. McGraw-Hill Medical, 578. ISBN 0-07-144040-2.
- ↑ Ganong, William F. (2005). Review of medical physiology. McGraw-Hill Medical, 577. ISBN 0-07-144040-2.