Flucloxacillin: Difference between revisions
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[[Image:Flucloxacillin structure.jpg|right|thumb|250px|{{#ifexist:Template:Flucloxacillin structure.jpg/credit|{{Flucloxacillin structure.jpg/credit}}<br/>|}}Flucloxacillin]] | |||
'''Flucloxacillin''' is a [[pencillin]]-like beta-[[lactam]] [[antibiotic]] that is an analog of [[cloxacillin]]. It is used to treat bacterial infections, mostly from aerobic gram-positive bacteria. Flucloxacillin, and all penicillin-like drugs, may cause anaphylactic shock. | |||
== Mechanism of action == | |||
Like other penicillin drugs, it inhibits the last stage of bacterial cell wall synthesis by binding to penicillin binding proteins, which inhibits the cross-linking needed to form stable cell walls. This leads to [[autolysis]] of the bacteria by [[autolysin]]s. | |||
== Chemistry == | |||
Its IUPAC chemical name is (2S,5R,6R)-6-[[3-(2-chloro-6-fluorophenyl)-5-methyl1,2-oxazole-4-carbonyl]amino]-3, | |||
3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid and it has molecular formula C<sub>19</sub>H<sub>17</sub>ClFN<sub>3</sub>O<sub>5</sub>S. Flucloxacillin is stable against degradtion by beta-[[lactamase]]s, including [[penicillinase]]s, and [[cephalosporinase]]s. | |||
== Drug interactions == | |||
Several drugs, including [[demeclocycline]], [[doxyclycline]], [[methacycline]], [[minocycline]]. [[oxytetracycline]], [[rolitetracycline]] and [[tetracycline]] may be antagonists of flucloxacillin. Flucloxacillin may decrease the effects of the contraceptive drugs [[ethinyl estradiol]] and [[mestranol]]. | |||
== External links == | |||
* {{DailyMed}} | |||
* Drug Bank [http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00301.txt] | |||
Revision as of 11:02, 11 February 2008
Flucloxacillin is a pencillin-like beta-lactam antibiotic that is an analog of cloxacillin. It is used to treat bacterial infections, mostly from aerobic gram-positive bacteria. Flucloxacillin, and all penicillin-like drugs, may cause anaphylactic shock.
Mechanism of action
Like other penicillin drugs, it inhibits the last stage of bacterial cell wall synthesis by binding to penicillin binding proteins, which inhibits the cross-linking needed to form stable cell walls. This leads to autolysis of the bacteria by autolysins.
Chemistry
Its IUPAC chemical name is (2S,5R,6R)-6-[[3-(2-chloro-6-fluorophenyl)-5-methyl1,2-oxazole-4-carbonyl]amino]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid and it has molecular formula C19H17ClFN3O5S. Flucloxacillin is stable against degradtion by beta-lactamases, including penicillinases, and cephalosporinases.
Drug interactions
Several drugs, including demeclocycline, doxyclycline, methacycline, minocycline. oxytetracycline, rolitetracycline and tetracycline may be antagonists of flucloxacillin. Flucloxacillin may decrease the effects of the contraceptive drugs ethinyl estradiol and mestranol.
External links
- Flucloxacillin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Drug Bank [1]