Interleukin-2: Difference between revisions
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'''Interleukin-2''' is an [[interleukin]] generated by [[lymphocyte#T4 helper cells|T4 helper lymphocyte]]s. It induces DNA synthesis in naive lymphocytes. Other terms include Lymphocyte Mitogenic Factor, T-Cell Growth Factor, Thymocyte Stimulating Factor and T-Cell Stimulating Factor.<ref>{{MeSH}}</ref> | '''Interleukin-2''' is an [[interleukin]] generated by [[lymphocyte#T4 helper cells|T4 helper lymphocyte]]s. It induces DNA synthesis in naive lymphocytes. Other terms include Lymphocyte Mitogenic Factor, T-Cell Growth Factor, Thymocyte Stimulating Factor and T-Cell Stimulating Factor.<ref>{{MeSH}}</ref> | ||
The gene expresses when stimulated by human T-cell leukemia virus Type 1.<ref>{{citation | |||
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1167238/pdf/emboj00174-0145.pdf | |||
| journal = EMBO Journal | volume = 5 | issue = 11 | pages =2883-2888 | |||
| year = 1986 | |||
| author = Jun-ichiro Inoue ''et al.'' | |||
| title = Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1}}</ref> | |||
[[Thalidomide]] has a costimulatory or adjuvant effect on [[T-lymphocyte]]s resulting in increased T-cell proliferation and increased production of interleukin-2 and [[interferon gamma]].<ref>{{citation | |||
| url = http://www.medscape.com/druginfo/monograph?cid=med&drugid=16389&drugname=Thalidomide+Oral&monotype=monograph&secid=8 | |||
| title = Monograph: Thalidomide — Pharmacology | |||
| author = Jun-ichiro Inoue ''et al.'' | |||
| publisher = American Society of Health System Pharmacists/Medscape | |||
}}</ref> | |||
==References== | ==References== | ||
{{reflist}} | {{reflist}} | ||
Revision as of 00:08, 19 August 2010
Interleukin-2 is an interleukin generated by T4 helper lymphocytes. It induces DNA synthesis in naive lymphocytes. Other terms include Lymphocyte Mitogenic Factor, T-Cell Growth Factor, Thymocyte Stimulating Factor and T-Cell Stimulating Factor.[1]
The gene expresses when stimulated by human T-cell leukemia virus Type 1.[2]
Thalidomide has a costimulatory or adjuvant effect on T-lymphocytes resulting in increased T-cell proliferation and increased production of interleukin-2 and interferon gamma.[3]
References
- ↑ Anonymous (2024), Interleukin-2 (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Jun-ichiro Inoue et al. (1986), "Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1", EMBO Journal 5 (11): 2883-2888
- ↑ Jun-ichiro Inoue et al., Monograph: Thalidomide — Pharmacology, American Society of Health System Pharmacists/Medscape