Kallikrein-kinin system: Difference between revisions
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Latest revision as of 11:00, 7 September 2024
The kallikrein-kinin system is a "system of metabolic interactions by products produced in the distal nephron of the kidney. These products include kallikrein; kinins; kininase I; kininase II; and enkephalinase. This system participates in the control of renal functions. It interacts with the renin-angiotensin-aldosterone system to regulate blood pressure, generation of prostaglandins, release of vasopressins, and water-electrolyte balance"[1]
Components and mechanisms
Kallikreins are serine endopeptidase (proteases) that act on kininogens to form the kinins bradykinin and kalidin.[2] There are three types of kallikreins:
- Tissue kallikrein
- Plasma kallikrein activates Factor XII to initiate the instrinsic pathway of coagulation.
- Prostate-specific antigen
Kininase I and kininase II inactivate bradykinin and kalidin.[3] Kininase II, formally called peptidyl-dipeptidase A, is the same enzyme as angiotensin converting enzyme.
References
- ↑ Anonymous (2024), Kallikrein-kinin system (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Ganong, William F. (2005). Review of medical physiology. McGraw-Hill Medical, 578. ISBN 0-07-144040-2.
- ↑ Ganong, William F. (2005). Review of medical physiology. McGraw-Hill Medical, 577. ISBN 0-07-144040-2.