Cefalotin: Difference between revisions

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'''Cefalotin''', also called '''sefalothin''',  is a semisynthetic first generation  [[cephalosporin]] [[antibiotic]] compound that is structurally similar to other cephalosporins including [[cefaclor]], [[cefadroxil]] and [[cefazolin]].   
'''Cefalotin''', also called '''sefalothin''',  is a semisynthetic first generation  [[cephalosporin]] [[antibiotic]] compound that is structurally similar to other cephalosporins including [[cefaclor]], [[cefadroxil]] and [[cefazolin]].   
It is administered [[parenterally]] to prevent infections during surgery or for treating a broad spectrum of infections  of the blood, bone or joints, respiratory tract, skin, and urinary tract.
It is administered [[parenterally]] to prevent infections during surgery or for treating a broad spectrum of infections  of the blood, bone or joints, respiratory tract, skin, and urinary tract.
== Chemistry ==
The IUPAC chemical name for cefalotin is (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid and it has chemical formula C<sub>16</sub>H<sub>16</sub>N<sub>2</sub>O<sub>6</sub>S<sub>2</sub>, giving it a molecular mass of 396.4380 g/mol.  The presence of a [[beta-lactam]] moiety makes it susceptible to degradation by [[beta-lactamase]s present in some bacterial strains.  The structure of cefalotin and other cephalosporins resemble those of [[penicillin]]s, but have a six-membered ring attached to the four-membered ring, wherease the penicillins have a five-membered ring attached to the four-membered ring.
== Mechanism of action ==
Like penicillin and other cephalosporins, cefalotin works by disrupting the last stage of bacterial cell wall synthesis, leading to [[autolysis]] of the bacteria cells by autolytic enzymes such as the [[autolysin]]s.  Some bacteria gain the ability to produce beta-lactamases, which can degrade the beta-lactam moiety present in penicillins and cephalosporins, and can thus be resistant to those drugs.
== Synonyms and brand names ==
* '''Synonyms'''
* Cefalotina
* Cefalotine
* Cefalotinum
* Cefalothin
* Cephalothin Sodium
* Cephalothinum
* Cephalothin
* Cephalotin
* CLS
* '''Brand Names'''
* Averon-1®
* Cemastin®
* Coaxin®
* Keflin®
* Seffin®
== External links ==
* {{CZMed}}

Revision as of 16:29, 5 April 2009

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(CC) Image: David E. Volk
cefalotin
IUPAC name: see chemistry section
Synonyms: cefalothin
Formula: C16H16N2O6S2
 Uses: antibiotic drug
 Properties: beta-lactam
 Hazards: see drug interactions
Mass (g/mol): CAS #:
396.4380 153-61-7


Cefalotin, also called sefalothin, is a semisynthetic first generation cephalosporin antibiotic compound that is structurally similar to other cephalosporins including cefaclor, cefadroxil and cefazolin. It is administered parenterally to prevent infections during surgery or for treating a broad spectrum of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.

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