Atherosclerosis: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>Joe Quick
m (subpages)
imported>Robert Badgett
mNo edit summary
Line 1: Line 1:
{{subpages}}
{{subpages}}
'''Atherosclerosis''' is defined as "thickening and loss of elasticity of the walls of medium and large muscular arteries with lesions in the innermost layer of the artery ( arterial intima). This disease process of atherogenesis includes the retention of cholesterol-rich lipoproteins and their binding to proteoglycans in the arterial intima, generation of proinflammatory molecules that recruit macrophages to the subendothelial space, formation of foam cells, and eventual calcification of the arterial wall. these arterial plaques (atheromas) contain carbohydrates; blood; and calcium."<ref name="title">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2007/MB_cgi?term=atherosclerosis |title=Atherosclerosis|author=National Library of Medicine |accessdate=2007-12-06 |format= |work=}}</ref>
'''Atherosclerosis''' is defined as "thickening and loss of elasticity of the walls of medium and large muscular arteries with lesions in the innermost layer of the artery ( arterial intima). This disease process of atherogenesis includes the retention of [[cholesterol]]-rich lipoproteins and their binding to proteoglycans in the arterial intima, generation of proinflammatory molecules that recruit macrophages to the subendothelial space, formation of foam cells, and eventual calcification of the arterial wall. these arterial plaques (atheromas) contain carbohydrates; blood; and calcium."<ref name="title">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2007/MB_cgi?term=atherosclerosis |title=Atherosclerosis|author=National Library of Medicine |accessdate=2007-12-06 |format= |work=}}</ref>


==Pathophysiology==
==Pathophysiology==

Revision as of 00:41, 22 February 2009

This article is a stub and thus not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.

Atherosclerosis is defined as "thickening and loss of elasticity of the walls of medium and large muscular arteries with lesions in the innermost layer of the artery ( arterial intima). This disease process of atherogenesis includes the retention of cholesterol-rich lipoproteins and their binding to proteoglycans in the arterial intima, generation of proinflammatory molecules that recruit macrophages to the subendothelial space, formation of foam cells, and eventual calcification of the arterial wall. these arterial plaques (atheromas) contain carbohydrates; blood; and calcium."[1]

Pathophysiology

Inflammation

Epidemiologic studies suggest the role of inflammation as atherosclerotic events are more common after recent infections.[2]

Complications

Common complications include coronary heart disease (including myocardial infarction and angina) and cerebrovascular disease (including and stroke and transient ischemic attack).

References

  1. National Library of Medicine. Atherosclerosis. Retrieved on 2007-12-06.
  2. Tim C. Clayton, Mary Thompson, and Tom W. Meade, “Recent respiratory infection and risk of cardiovascular disease: case-control study through a general practice database,” Eur Heart J (December 6, 2007), http://eurheartj.oxfordjournals.org/cgi/content/abstract/ehm516v1 (accessed December 6, 2007).